News

FET Launchpad funding awarded to MESO-BRAIN partners

ICFO receives funding to continue breakthrough technology for developing new imaging technology.

ICFO, a partner in EU-funded MESO-BRAIN project (GA # 713140), has had a new related proposal selected for EU funding in the FET Launchpad scheme. MAFIn(Module for Aberration Correction and Fast Volumetric Imaging in a Light Sheet Fluorescence Microscope), builds on ideas that originated in the MESO-BRAIN project.

Starting in September 2019, the SLN Lab team within the SLN facility led by Dr. Pablo Loza-Alvarez, are constructing a modular microscope prototype that is capable of observing the fast cellular and intracellular dynamics that occur in biological samples in 3D with high resolutions and at speeds approaching 100vps. One example of a targeted application is fast functional imaging, such as the calcium dynamics in the brain.

The MAFIn module will be tested for measuring the fast electrical activity in connected functional 3D neural networks. A wide range of potential biomedical researchers interested in studying other fast biological dynamics in 3D are the intended users of the module.

In addition, the module will be developed to be easily attached to any existing Light Sheet Fluorescence microscope (LSFM) and intrinsically be able to correct for aberrations, providing sharp information of the fast 3D process to be studied.

Available only to existing or recently ended FET projects, the FET Launchpad scheme aims to encourage the development of innovative ideas emerging from a project to be accelerated through separate and targeted Launchpad funding.

MESO-BRAIN partners Aston University (working in collaboration with Laser nanoFAB GmbH) and Axol Bioscience, also succeeded in having their own FET Launchpad proposals selected for funding with Scaffold-Needs and COMMER-CELL respectively.

The MAFIn project (Module for Aberration Correction and Fast Volumetric Imaging in a Light Sheet Fluorescence Microscope) aims to develop a robust and easy-to use modular device capable of fast volumetric imaging at high spatial resolution to be installed in existing light sheet fluorescence microscopes (LSFM).

A one-year EU-supported project at ICFO, a photonics research institute based in Barcelona, aims to develop a modular light-sheet microscopy prototype able to observe fast cellular dynamics at high resolution and high speed. Light-sheet fluorescence microscopy (LSFM) is a technique in which a thin …

Meso-brain at Brain Awareness Week (BAW)

MESO-BRAIN is officially a registered partner of Brain Awareness Week (BAW).

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3D imaging of neurons in hydrogel

3D imaging of neurons in hydrogel obtained at ICFO on a sample prepared by UB. Active neurons were observed in 5 layers.

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Meso-brain at Edinburgh University’s 7th Annual Neuroscience to Neurology day

We are pleased to announce that MESO-BRAIN’s Derek McKenzie will be participating in Edinburgh University’s 7th Annual Neuroscience to Neurology day on the 2nd of March 2019 to introduce the leading-edge work of the project to a new generation of young researchers

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MESO-BRAIN on Television

We are delighted to be able recommend a television programme – Operation Ouch on BBC iPlayer – which features the MESO-BRAIN programme. MESO-BRAIN is featured in episode 6 of series 7 which went out out on CBBC at 17:30 on Wednesday 02 January 2019. The programme is available on the BBC iPlayer.

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Laser structured 3D scaffolds for development of 3D neuronal networks

The video provides an instructive example of the enabling power of well-engineered 3D scaffold platforms. An iPSCs-derived neuronal cell network developed on 3D laser produced scaffold at day 69 of neuronal differentiation is presented. The video has been reconstructed from a stack of confocal microscopy images. Neurons are green (MAP2 staining), red dots are synaptic connections (PSD95 staining ), and blue are cell nuclei. Laser structured 3D scaffold represent a great artificial platform for the development of 3D neuronal networks. Obtained neuronal cell populations are currently undergoing thorough characterization using additional markers.

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MESO-BRAIN poised for final year delivery

The MESO-BRAIN project met in the splendid setting of the Medical School Buildings at the University of Barcelona for a review of progress at the end of Year 2 and planning for the final 12 months of the project.

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Meso-brain makes recordings with iPSC cell cultures

As the project heads into the last 12 months of activity, recent recordings of Axol iPSC cell cultures show great promise for the achievement of the final results.

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The Brain Conferences: Cortex Development and Evolution (FENS) – Blog from James Crowe

FENS, The Brain Prize and IBRO-PERC stipend recipient, James Crowe attended The Brain Conferences: Cortex Development and Evolution (FENS), which took place in Copenhagen, Denmark. James is a PhD candidate at the Department of Life and Health Sciences, Aston University, UK. His research focuses upon building human cortical networks-in-a-dish using iPSC-derived neural stem cells, with the aim of exploring network connectivity. James discusses his attendance of the conference where he presented his research.

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